Virtual PBX Helps to keep Everyone In Touch | Business Phone ...

Also referred to as hosted PBX, virtual PBX is a distinguished telephone system inclusive of advanced features and functions. In addition, this phone system needs business voip phone service, allowing voicemails together with other mode of communications faster and even more productive. As a consequence of deficient IT spending plan and also resources, quite a few organizations is not able to acquire a refined communication system. Then again, by making use of hosted PBX, you may get to this dream without spending considerably. Right here are the usual features this system is able to offer.

? Convenient to use
Due to the significant features a virtual PBX may offer, there is a rising interest in this phone system. No matter what where you are, it?s easy to get connected to the workers, customers, business partners, along with other contacts in case you have hosted PBX. Given that it takes advantage of the web to have a person connected, so long as a pc with internet access exists, it?s easy to call your contacts and also get and send out messages anytime and anyplace. Beneficial functions including call forwarding and also follow-me capabilities will let you get calls in your telephone or residential land line. Phone callers may well give messages which you could tackle later on. Apart from, should you want to strengthen your business communications and evaluate call traffic, the visual call reports could be prompted at realtime.

? User friendly
The virtual PBX systems can be slightly managed with out challenges due to its online cpanel. Numerous company extensions are able to keep a single phone number which can be useful to check out fax messages, voicemails, and even valuable calls. It is also by making use of business VoIP systems. Telephone calls are directed to good areas or even business units, steering clear of the chances of phone callers having missed calls or even busy tones.

? Less expensive
There?s a multitude of capabilities that you may take pleasure in should you register for a virtual PBX system. You can hold conference meetings on the web and easily share documents and also presentations to a quantity of users. And also the great thing with it is basically that you won?t be faced with highly-priced bills. Actually, you?ll be able to benefit from the various capabilities just like extension dialing, call forwarding, toll free numbers, conference calling, voice mailing, caller ID, and much more with just a minimum rate per month. Besides, enhanced functions just like voice mail transcription, unified communication, call hunt groups, simultaneous ring, live call park, and more are possible by adding only a small extra fee.

? Simple contact management
Virtual Private Branch Exchange (PBX) employs online interface, so that it is a convenient option for company to address consumers and also contacts from other existing phone system. If ever the business expands, nearly all aspect of the company gets bigger, as well as manpower, product sales, and communication system. A growing company requires a scalable communication system that can take on the growing call requirements of your company. Utilizing this type of phone system, you can certainly remove and add in contacts and retain the present from your old phone system.

The good thing about employing PBX is something you?ll want to consider if you wish to give your company an advanced and arranged communication system.

Source: http://www.mybusinessphoneservices.com/2012/12/virtual-pbx-helps-to-keep-everyone-in-touch/

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Petrol strike threatens to cause chaos and hit economy in Italy

ROME (Reuters) - Italian petrol stations began a 60-hour strike late on Tuesday to protest against rising costs and falling profits, causing long queues as drivers rushed to fill up before pumps closed.

Hitting at the peak shopping period before Christmas, the strike comes at unwelcome time for retailers. Weak consumer spending has been a key factor in Italy's sluggish economy, which has been dipping in and out of recession since 2008.

"It is incredible, with all that petrol costs us nowadays, that they can even think of going on strike," Rome resident Ida Lauro said as she queued in her car.

Unions have agreed to maintain minimum service on motorways, with at least one station open every 100 km (62 miles).

In a joint statement, unions said they called the strike to combat "a true aggression against the roughly 24,000 small businesses and 120,000 workers in the sector".

They say oil companies have forced stations to absorb the costs of discounting campaigns, allowing them a profit of just one euro for every 100 euros ($130) or 55 liters of petrol sold.

Oil distributors in Italy Esso and Shell were not immediately available for comment. A government attempt to come to an agreement with the unions this week fell through.

Workers will demonstrate outside government buildings in Rome on Wednesday to pressure the state to intervene.

The strike will end on Friday morning on ordinary roads and late on Thursday on motorways.

Between December 17 and 22 the petrol stations will refuse to pay oil companies for refills. Then, between Christmas and New Year, they will refuse credit and debit card payments in protest at bank charges on electronic payments.

Mario Monti's technocrat government has cut spending and raised taxes since it was appointed last year to pull Italy out of a debt crisis, and is the focus of increasing protests.

The government was thrown into crisis last week when the party of former Prime Minister Silvio Berlusconi withdrew its support, prompting Monti to announce he would resign once the 2013 budget bill is passed before Christmas.

(Reporting by Eleanor Biles and Naomi O'Leary)

Source: http://news.yahoo.com/petrol-strike-threatens-cause-chaos-hit-economy-italy-185214992--finance.html

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Resurrection of extinct enzymes reveals evolutionary strategy for the invention of new functions

Resurrection of extinct enzymes reveals evolutionary strategy for the invention of new functions

Wednesday, December 12, 2012

How does evolution innovate? We exist because our ancestors have had the ability to adapt successfully to changes in their environment; however, merely examining present-day organisms can limit our understanding of the actual evolutionary processes because the crucial events have been masked by the passage of aeons ? what we need is a time machine. Scientists from VIB, KU Leuven, University of Ghent and Harvard have done the next-best thing; by reconstructing DNA and proteins from prehistoric yeast cells, they were able to directly examine the evolutionary forces that have acted over the last 100 million years to shape modern-day enzymes ? biological catalysts that enable organisms to manipulate molecules to their will.

The scientists set out to explore how new genes emerge, how they contribute to the survival of the evolving organism, and how, after a humble start, evolution then refines the function of new genes and hones the efficiency of the enzymes that they encode. One of the richest sources of such new genes is the chance duplication of existing genes. One copy of the gene can then continue to encode the original enzyme, allowing it to perform its original task, while the other is free to change and to perhaps take on a new function; alternatively, the two new enzymes might sub-divide the original task.

Although this pattern of innovation is known to have happened many thousands of times during evolution, the way in which it occurs hasn't been clear. In a paper published December 11 in the online Open Access journal PLOS Biology, Karin Voordeckers, Chris Brown and Kevin Verstrepen from VIB in Leuven, together with Steven Maere from VIB and the University of Ghent, tackled this problem, focusing their attention on the evolution of enzymes that have allowed yeast to exploit changing food sources over the last 100 million years of evolution.

The scientists 'resuscitated' ancestral yeast genes, allowing them to examine the properties of enzymes that existed tens of millions of years ago. The original enzyme originally enabled the yeast cells to survive on a diet of maltose, a common sugar, but duplications of their genes gave rise to new enzymes which opened up the possibility of feeding off other types of sugar in the environment. The resurrection of these enzymes meant that the scientist could build up a detailed picture of their atomic structure and directly determine their ability to break down different types of sugars. Armed with this information, they could work out exactly how the enzymes had changed their specificity and how evolution drove their optimisation.

"We used sequence reconstruction algorithms to predict the DNA sequence of ancestral genes from dozens of present-day DNA sequences. This enabled us to rebuild the corresponding ancestral proteins and compare them with those present today", said Steven Maere.

"We searched very specifically for how the yeast adapted to break down various sources of sugar. We found that the primal gene that codes for the protein for the digestion of maltose ? a sugar in grain ? was copied a number of times during evolution. The DNA of some copies changed slightly, resulting in new proteins that could break down different sugars. By modeling these changes in the corresponding proteins, we now understand how just a few changes in the DNA can lead to the development of a completely new activity in the corresponding proteins", said Karin Voordeckers.

"New functional DNA does not appear out of thin air, but is built up gradually from a copy of an existing segment of functional DNA. By reconstructing a piece of prehistoric DNA that was copied several times during evolution, we were able to investigate in detail which changes occur in each of the copies and gradually lead to new functions. As such, our results provide a unique and detailed view into the molecular details of Darwinian evolution" says Kevin Verstrepen.

The scientists propose that the events observed here in the yeast cell's quest for sugar may reflect a general strategy widely used for innovation in evolution.

###

Public Library of Science: http://www.plos.org

Thanks to Public Library of Science for this article.

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Source: http://www.labspaces.net/125883/Resurrection_of_extinct_enzymes_reveals_evolutionary_strategy_for_the_invention_of_new_functions_

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Exams Ethics Hold Confab | Daily Guide Newspaper

From right Kofi Ashiboe-Mensah, Professor Anthony Panin and a member of the organisation at the launch

In line with promoting ethics, integrity and best practices in education, Exams Ethics International, a non-governmental organisation with the objective of creating awareness on examination malpractices, has launched the 2012 Exams Ethics Marshals International Conference and Awards in Accra.

The conference, to be held in collaboration with the Ghana Education Service from December 10 ? 14, 2012, is on the theme ?Imperative Leadership, Management and Administrative Best Practices for Educational MDA?s and Institutions to rank among the best in the World?.

It is expected to bring together heads of institutions and departments, university professors, directors of education, examination officers and teacher associations from Ghana and Nigeria to deliberate on how to manage the educational systems, with particular reference to examination.

Kofi Ashiboe-Mensah, country director of Exams Ethics International, said the conference was crucial and timely, considering the increased number of students in both private and public universities as well as the pending 2013 WASCE exams.

He said, ?Concrete measures must be put in place, in structure and content, to ensure the delivery of quality education at all levels of the educational system in the country.?

Ashiboe-Mensah said the conference would, among other things, inform stakeholders about the need to eradicate examination malpractices from the educational system as well as bring together Nigerians and their Ghanaian counterparts to share experiences that would impact on their performance.

He also called for parents and teachers to help the children study so as to be prepared for the exams in order to avoid cheating during examinations.

?The children must be taught how to manage their time and study for the exams so when the time comes they will have the confidence to write without cheating,? he said.

Professor Anthony Panin, council chairman of Kadosh College of Management and dean of the Faculty of Economics, Central University College, in his address, said ethical and moral values could be transmitted to the youth only through effective education.

He stated, ?It is the belief of the organisation that unless education is effectively used as an instrument for forging and transmitting ethical values to the youth, all other efforts at promoting ethical and moral values, leadership development and good governance will come to naught.?

He was therefore hopeful the noble cause of the organization would be achieved.

Personalities, institutions and organizations will also be honoured at the conference for their support towards the initiative of Exams Ethics International.

By Jamila Akweley Okertchiri

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Source: http://www.dailyguideghana.com/?p=70082

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U.S. and Russia still back Syria settlement: U.N. envoy

BEIRUT (Reuters) - U.S. and Russian officials have given their commitment to a political solution for the deepening Syrian conflict, a United Nations envoy said on Sunday, but Moscow dismissed speculation it was preparing for President Bashar al-Assad's exit.

With rebels now fighting on the doorsteps of Damascus, Assad's forces kept up their now daily artillery strikes and air raids on eastern suburbs as well as some rebel-held districts on the capital's outskirts.

U.N. special envoy Lakhdar Brahimi met the U.S. and Russian deputy foreign ministers in Geneva for the second session of tripartite talks in less than a week, apparently in response to rising violence that now threatens to engulf Damascus.

"All three parties reaffirmed their common assessment that the situation in Syria was bad and getting worse," a statement from Brahimi said. "They stressed that a political process to end the crisis in Syria was necessary and still possible."

Notwithstanding his comments, commitment to a political process could be at risk. Western officials were among those who helped rebels to create a unified chain of command at the weekend, and Washington is expected to recognize the opposition as the sole representative of the Syrian people next week.

Russia, Syria's main arms supplier, insisted its position on Assad had not softened and it was not negotiating on the future of the president, whose family has ruled Syria for 42 years.

"We are not holding any talks on the fate of Assad," Foreign Minister Sergei Lavrov was quoted as saying by Itar-Tass news agency in Moscow. "All attempts to present the situation rather differently are shady."

Several countries are believed to be supplying both sides in the conflict, with Iran bankrolling Assad's war efforts while its regional rivals Saudi Arabia and Qatar arm the rebels.

Brahimi said the talks aimed to find a solution based on last June's Geneva Declaration, which called for a transitional government. This proposal originally foundered over different interpretations of that transition; Washington said Assad could not play a role but Russia insisted that his fate should not be decided outside Syria.

Syria's 20-month-old uprising, which began as peaceful protests but has descended into civil war, has become increasingly bloody with over 40,000 people killed.

RADICALS ON THE RISE

The rebels have gained momentum in recent weeks, capturing a series of military sites across the country often with the help of radical Islamists. However, some activists believe the opposition is still far from toppling Assad, whose army has largely held together and who has many heavy weapons.

The Syrian Observatory for Human Rights reported army shelling and clashes across the country on Sunday, with 60 counted dead before evening. Death tolls have averaged at around 100 per day in recent weeks.

In the north, the radical Islamist group Jabhat al-Nusra, linked to Al Qaeda in Iraq, led other rebels in seizing on Sunday a regimental command center in Aleppo province, which borders Turkey.

The British-based Observatory, which has a network of activists across the country, said the centre's commander fled along with 140 soldiers. Five troops soldiers were captured.

Western powers have become increasingly alarmed by the role of groups such as Jabhat al-Nusra, which Washington is considering putting on its terrorist list.

Radical groups have gained increasing popularity and influence despite their small numbers. The seasoned fighters they attract from Syria and abroad have increased the effectiveness of their attacks.

Some rebels and residents feel the militants are more disciplined than other rebels, drawing fewer charges of looting and kidnapping.

ROAD TO DAMASCUS?

Damascus has become a focal point of battles over the past week, as rebels effectively shut the international airport by clashing with Assad's forces near there. Foreign flights have been suspended and residents say the airport road is closed.

Rebels who have called their campaign "Operation Opening the Road to Damascus", uploaded video on Sunday that showed heavy gunbattles and explosions rocking several rural towns around the capital. The video also showed rebels firing a fully functioning tank which they had captured from the army.

But there is no clear winner yet in a battle where neither side seems to have advanced. The Syrian army has claimed many successes around the capital, airing footage on state television of soldiers raiding parts of the rebel stronghold of Deraya.

"Our noble forces in Deraya have destroyed some of the terrorist dens used by al Qaeda terrorists to store weapons and other criminal tools," said a report on Syria TV, which usually refers to rebels as terrorists. "Many terrorists were killed."

Still, rebel gains have helped drive a surge of diplomatic efforts among Gulf Arab states and the West to support the opposition and its newly-formed umbrella group, the Syrian National Coalition.

The move may be encouraging defections. Nine judges defected in a YouTube video published on Sunday. Such videos, however, are difficult to verify as the Syrian government has restricted media access in the country.

(additional reporting by Stephanie Nebehay in Geneva and Nastassia Astrasheuskaya in Moscow,; editing by David Stamp)

Source: http://news.yahoo.com/u-russia-still-back-syria-settlement-un-envoy-045743835.html

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North Korea looks set to delay controversial rocket launch

SEOUL (Reuters) - North Korea will likely postpone the launch of a long-range rocket, state news agency KCNA said on Saturday, but gave no reasons for delaying the plan which has been widely condemned by countries including Russia and the United States.

KCNA quoted a spokesman for the country's space agency, which plans to send a satellite into space on the rocket, as saying it was "seriously examining the issue of readjusting the launching time of the satellite".

North Korea, which planned to launch the rocket between December 10 and December 22, is banned from carrying out any missile or nuclear related tests by United Nations resolutions imposed in 2006 and 2009 after it conducted nuclear tests.

The latest launch had been scheduled to take place around the first anniversary of the death of North Korea's former leader Kim Jong-il but would also have coincided with December elections in Japan and South Korea.

The planned launch has been condemned by Japan and South Korea, as well as the United States and Russia. China, the North's only major diplomatic ally, has expressed "deep concern" it could raise tensions on the Korean Peninsula.

The rocket was scheduled to pass between the Korean Peninsula and China, with a second stage splashing down off the Philippines before launching the satellite into orbit.

An earlier launch attempt ended in failure in April when the mission was aborted just a few minutes into its flight.

Critics say North Korea's rocket program is aimed at developing an ballistic missile capable of delivering a nuclear warhead.

(Reporting by Choonsik Yoo and David Chance; Editing by Sophie Hares)

Source: http://news.yahoo.com/north-korea-says-may-alter-rocket-launch-dates-170815649.html

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AP NewsBreak: FBI says Alaska man killed for fun

This undated photo provided by the FBI shows a Home Depot bucket containing gun parts, ammunition and other items discovered at a Parishville, N.Y. reservoir after a man jailed in Alaska admitted to a series of killings, including an Anchorage barista and a couple from Vermont. (AP Photo/FBI)

This undated photo provided by the FBI shows a Home Depot bucket containing gun parts, ammunition and other items discovered at a Parishville, N.Y. reservoir after a man jailed in Alaska admitted to a series of killings, including an Anchorage barista and a couple from Vermont. (AP Photo/FBI)

This undated photo provided by the FBI shows Israel Keyes. Keyes committed suicide in an Alaska jailhouse Sunday, leaving behind an incomplete picture of a loner who traveled the country for more than a decade, picking victims at random and methodically killing them. (AP Photo/FBI)

This undated photo provided by the FBI shows bottles of Drano found inside a plastic bag in Eagle River, Alaska, just north of Anchorage. The FBI says confessed Alaska serial killer Israel Keyes, who targeted people across the country, told authorities he planned to strike again in the state if he had gotten away with the murder of an 18-year-old Anchorage barista. (AP Photo/FBI)

FILE - In this undated file photo provided by the Anchorage Police Department shows Anchorage, Alaska, barrista, Samantha Koenig, 18, is pictured. Investigators say Israel Keyes, found dead Sunday, Dec. 2, of an apparent suicide in an Anchorage, Alaska jail, was not only suspected of killing Koenig but may be linked to seven other possible slayings around the country, including the Curriers, of Essex, Vt.. The bodies of the Curriers have never been found. They were last seen leaving their jobs on June 8, 2011. Anchorage police chief Mark Mew said Keyes confessed to killing Koenig, as well as killing Bill and Lorraine Currier. Keyes, 34, also indicated he killed four others in Washington state and one person in New York state, but didn't give the victims' names, authorities said. (AP Photo/Anchorage Police Department)

FILE - In this undated file photo provided by the Essex, Vt., police, Bill and Lorraine Currier are seen. Investigators say Israel Keyes, found dead of an apparent suicide in an Alaska jail, was not only suspected of killing Anchorage barista Samantha Koenig but may be linked to seven other possible slayings around the country, including the Curriers, of Essex, Vt.. The bodies of the Curriers have never been found. They were last seen leaving their jobs on June 8, 2011. Anchorage police chief Mark Mew said Keyes confessed to killing Koenig, as well as killing Bill and Lorraine Currier of Essex, Vt. Keyes, 34, also indicated he killed four others in Washington state and one person in New York state, but didn't give the victims' names, authorities said. (AP Photo/Essex police, File)

ANCHORAGE, Alaska (AP) ? Investigators who spent hours interviewing an Alaska serial killer say he may have murdered close to a dozen people, and that he killed for pleasure and was only conflicted about how his notoriety would affect his loved ones.

Israel Keyes confessed to killing eight people across the country before he committed suicide last weekend in an Anchorage jail, but FBI and Anchorage police investigators said Friday they think he may have had up to three additional victims.

"Based on some of the things he told us, and some of the conversations we had with him, we believe the number is less than 12," FBI Special Agent Jolene Goeden said. "We don't know for sure. He's the only one who could have ultimately answered that."

Keyes slit his wrist and strangled himself with bedding Sunday at the Anchorage Correctional Facility. He was facing federal murder charges in the kidnapping and death of an 18-year-old Samantha Koenig, who was abducted from an Anchorage coffee stand Feb. 1.

Goeden and Anchorage Police officer Jeff Bell conducted up to 40 hours of interviews with Keyes after his March arrest in Texas. During that time, Keyes confessed to killing Koenig, along with Bill and Lorraine Currier in Vermont, and five other people ? although details for those victims were scarce.

The interviews also revealed Keyes' motivation, which was simple, Goeden and Bell told The Associated Press.

"He enjoyed it. He liked what he was doing," Goeden said. "He talked about getting a rush out of it, the adrenalin, the excitement out of it."

Keyes also liked seeing coverage of his crimes in the media, and he appeared to get a thrill out of talking about some of them with investigators, Goeden and Bell said.

His crimes started small with burglaries and thefts ? until the urge escalated to murder.

Bell said Keyes told investigators the first violent crime he committed was a sexual assault in Oregon, in which he let the victim go.

"He planned on killing her but didn't," Bell said.

Keyes said the rape occurred sometime between 1996 and 1998 along the Deshutes River near Maupin, Ore., after he got the girl away from her friends. The girl was between the ages of 14 and 18, and would be in her late 20s or 30s now. No police reports were filed, and the FBI is seeking more information on the crime.

Of the five other murders Keyes confessed to, four were in Washington state and one occurred on the East Coast, with the body disposed of in New York.

In the case of the Curriers, authorities say Keyes flew from Alaska to Chicago on June 2, 2011, rented a car and drove almost 1,000 miles to Essex, Vt.

There, he carried out a "blitz" style attack on the Curriers' home, bound the couple and took them to an abandoned house. Bill Currier was shot, and his wife was sexually assaulted and strangled.

Keyes immediately returned to Alaska, and followed the case on his computer by monitoring Vermont media. The couple's bodies were never found after the house was demolished and taken to a landfill.

Leaving the area shortly after a murder was a familiar tactic for Keyes. After he abducted Koenig, he took her to a shed at his Anchorage home, sexually assaulted her and strangled her.

Keyes then left the next day for a two-week cruise, storing Koenig's body in the shed. Upon his return, he dismembered the body and disposed of it in a lake north of Anchorage. He was later arrested in Texas after using Koenig's debit card.

Koenig was his only known victim in Alaska. Goeden and Bell said he never explained why his broke his own rule of never killing anyone in the town where he lived because it's easier to be connected to such a killing.

The only mistake Keyes said he made was letting his rental car be photographed by an ATM when withdrawing money in Texas.

Unlike his earlier killings, the deaths of the Curriers and Koenig received a lot of news coverage.

"He was feeding off the media attention in the end," Bell said.

That wasn't the only change. His time between murders was growing shorter.

"He talked about that time period in between crimes, that over the last few years, that became quicker," Goeden said.

During their interviews, Keyes was willing to talk about the Koenig and Currier killings since he knew authorities had evidence against him.

"It was chilling to listen to him. He was clearly reliving it to a degree, and I think he enjoyed talking about it," Bell said of the Koenig and Currier deaths. But in the other cases, Keyes wasn't as forthcoming because he knew investigators had little on them.

Keyes, a construction contractor, told investigators that they knew him better than anyone, and that this was the first time he'd ever spoken about what he called his double life.

"A couple of times, he would kind of chuckle, tell us how weird it was to be talking about this," Bell said.

Even though he was talking to investigators, Keyes didn't want his name made public in any of the other investigations, especially the Curriers, because of the fallout of publicity. He threatened to withhold information if his name got out

"If there was nobody else that he was concerned about, I think he wanted his story out there. He wanted people to know what he did," Goeden said. "What he was worried about is the impact that was going to have on the people that cared about him and were close to him."

Keyes will be buried Sunday in Washington state. His mother and four of his nine siblings were traveling to the funeral, his mother's pastor, Jacob Gardner, told the Anchorage Daily News.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-12-07-Alaska%20Serial%20Killer/id-8fe428dc425b4f3ab82717c9c8c1c717

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